Several common risk factors and associated pathophysiologic mechanisms are shared between dementia and POAG, including intracranial pressure changes and associated increased IOP, optic nerve and RGC degeneration, cerebrospinal fluid circulatory failure and sequestration, and the presence of both amyloid-β and tau proteins, known for their role in Alzheimer’s disease (AD) [4,5,6,7,8,9,10,11]. This evidence concerns the gene MAPT and Alzheimer disease.