The patients who had abnormal findings on a brain CT (n = 12, 25.5%), such as hypoxic-ischemic brain injury (n = 7, 14.9%), ischemic stroke (n = 4, 8.5%), and intracranial hemorrhage (n = 1, 2.1%), consistently exhibited significantly higher NSE levels at all time points compared to those with normal findings (118.0 [IQR, 71.9–142.0] vs. 47.5 [IQR, 35.7–68.5], p = 0.002 at 24 h; 178.8 [IQR, 88.1–216.5] vs. 44.0 [IQR, 37.1–96.7], p = 0.002 at 48 h; 140.3 [IQR, 62.1–345.2] vs. 39.1 [IQR, 26.7–77.2], p = 0.003 at 72 h). This evidence concerns the gene ENO2 and ischemic stroke.