The level of adiponectin is low in conditions associated with obesity and an increased level of inflammation, such as in patients affected by GDM [24,25], T2DM [26], colorectal cancer [27], ovarian cancer, and endometrial [28] or cardiovascular diseases [29]; or paradoxically, it is increased in some patients with cardiovascular and renal diseases [29,30]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.