However, anti-VEGF therapy carries risks, including reactivation requiring repeat injections, the need for frequent follow-ups, and increased risks of conjunctival and retinal hemorrhage, elevated intraocular pressure, retinal and choroidal ischemia, worsening retinal traction, cataracts, intraocular inflammation, retinal detachment, and potential systemic effects. The gene discussed is VEGFA; the disease is cataract.