P2RY12 and myocardial infarction: Antiplatelet therapy is widely used for the secondary prevention of stroke, myocardial infarction (MI), and peripheral arterial disease, with such patients typically receiving single antiplatelet therapy with acetylsalicylic acid (ASA) or dual antiplatelet therapy with ASA and a P2Y12 inhibitor such as clopidogrel or ticagrelor.