It has been observed that hyperglycemia can play a protective role in impeding apoptosis in tumor cells, which is brought about by the specific inhibition of Serine 46 phosphorylation, a known activator of p53, and cytochrome C-mediated apoptosis by glucose-induced increased glutathione (GSH) synthesis in tumor cells [46,47]. The gene discussed is TP53; the disease is Hyperglycemia.