Using a T2DM and a control cohort from the Asir region of Saudia Arabia, we looked into the association between the pro-inflammatory chemokines CCL1, CCL2, CCL4, and CCL5 and the etiopathogenesis of T2DM in subjects with different degrees of obesity, BMI, and HbA1c. The gene discussed is CCL4; the disease is obesity due to melanocortin 4 receptor deficiency.