Using a T2DM and a control cohort from the Asir region of Saudia Arabia, we looked into the association between the pro-inflammatory chemokines CCL1, CCL2, CCL4, and CCL5 and the etiopathogenesis of T2DM in subjects with different degrees of obesity, BMI, and HbA1c. Here, CCL1 is linked to obesity due to melanocortin 4 receptor deficiency.