With this background, we intend to study the relationship between pro-inflammatory chemokines CCL1, CCL2, CCL4, and CCL5 and the etiopathogenesis of T2DM in subjects with varying levels of obesity, BMI, and HbA1c in a patient cohort from the Asir region of Saudia Arabia. This evidence concerns the gene CCL4 and obesity due to melanocortin 4 receptor deficiency.