Although a few studies reported lower levels of CCL-2 in the prediabetic state, our results are partly consistent with earlier studies that reported higher levels of CCL2 in prediabetes, T1DM, and T2DM in general, as there was no further subdivision on the basis of BMI and level of obesity in those studies [2,3,8,22]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.