In addition, besides inducing apoptosis through the PI3K/Akt/mTOR and NF-kB pathways, EGCG and curcumin could also exert radiotherapy-induced cancer cell death by activating the miR-34a/Sirt1/p53 signaling pathway or inhibiting the MAPK pathway, respectively [13]. The gene discussed is AKT1; the disease is cancer.