Similar results were shown by Menghoum et al., with the mean glycemia level being 15.69 mmol/L, an HbA1c of 8.9 ± 2.2%, a pH of 7.2 ± 0.17, serum bicarbonate levels of 10.5 ± 5.8 mmol/L, and lactate levels of 1.7 ± 1.3 mmol/L despite the substantial use of metformin in 88% of patients studied, again confirming that lactic acidosis is an unlikely driver of the metabolic acidosis seen in SGLT-2-inhibitor-induced EDKA [28]. This evidence concerns the gene SLC5A2 and metabolic acidosis.