Associations of genotypes or haplotypes in ADRB1, CYP3A5, and NEDD4L polymorphisms (i.e., those with p < 0.05 and trended towards significance at univariate analysis) with RHTN after adjusting for aldosterone levels, dyslipidemia, diabetes mellitus and use of statins or lipid-lowering therapy are shown in Table 4. The gene discussed is NEDD4L; the disease is metabolic syndrome.