Additionally, Pang et al. (2023) identified Yes-associated protein (YAP)-galectin-3 signaling as a mediator of endothelial dysfunction in angiotensin II-induced hypertension, emphasizing the detrimental effects of galectin-3 on vascular homeostasis and endothelial function [69]. The gene discussed is LGALS3; the disease is endothelial dysfunction.