In the present study, a positive correlation was detected between SP-D and proSP-B with s-RAGE in CHD patients, with and without diabetes (groups DC and NC, respectively), suggesting a possible link between serum levels of surfactant proteins and cardiovascular risk condition, because plasma levels of sRAGE may be associated with plaque vulnerability in patients with CHD, according to previous studies [38,39]. The gene discussed is AGER; the disease is coronary artery disorder.