Increased CRP levels are associated with factors such as unhealthy lifestyle (smoking, sedentary behavior, and higher BMI), metabolic disorders (obesity, low HDL-C, high LDL-C, elevated TG levels, hypertension, metabolic syndrome, and diabetes mellitus), chronic infections, inflammatory conditions, and the use of estrogen and progesterone therapies. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.