TNF and type 2 diabetes mellitus: Yet, in addition to preventing hyperglycemic symptoms associated with T2DM, Grifola frondosa polysaccharide, as an important prebiotic, could alleviate systemic and local inflammation, reduce key inflammatory regulators TNF-α and NF-κB p65 in skeletal muscle resulting from T2DM-induced intestinal barrier dysfunction, and mitigate the consequent atrophy of skeletal muscle.