PSEN1 and Alzheimer disease: Another study evaluated the effect of gallic acid in the transgenic AD mouse model of mutant human amyloid β-protein precursor/presenilin 1 (APP/PS1) and found that gallic acid attenuated cerebral amyloidosis, including brain parenchymal and cerebral vascular β-amyloid deposits, and reduced cerebral amyloid β-proteins [53].