UCP1 and obesity due to melanocortin 4 receptor deficiency: However, the expression of UCP1 in BAT was elevated and the browning transformation of subcutaneous adipose tissues was activated by the administration of PTP (Figure 6), indicating that the protective effects of PTP on obesity might be closely associated with increased energy expenditure, as evidenced by upregulating the UCP1 expression in BAT and the browning of white adipose tissue in PTP-treated mice.