EPHX2 and Insulin resistance: Regarding these enriched pathways, the cytochrome P450 pathway and the CYP epoxygenase-EET-sEH system play important roles in the onset and development of insulin resistance and can delay the development of insulin resistance caused by fructose dietary intake by upregulating genes such as Cyp2j3, Cyp2e1, and Cyp1a2 [20,21].