Monoclonal antibodies against AMD inhibit tumor growth and enhance the antitumor effect exerted by temozolomide (in temozolomide-resistant glioma samples, overexpression of AMD has been reported); this inhibition has also been observed when the tetracyclic diterpenoid ester ingenol mebutate was administered by inhibiting the effects mediated by AMD [7,137]. The gene discussed is AMD1; the disease is age-related macular degeneration.