To the contrary, other peptides exert anti-glioma effects (antiproliferative, antimigration, anti-invasion, and anti-angiogenic): angiotensin (1-7) fragment, carnosine, CRF, methionine-enkephalin, Gn-RH (goserelin acetate), LH-RH (AN-152), Tat-Cx43266-283, Tat-NTS, PACAP, PACAP-27, PACAP-38, and somatostatin (Figure 1 and Table 1) [69,78,83,85,88,92,93,94,95,101,108,116]. The gene discussed is CRH; the disease is central nervous system cancer.