NME2 and lung carcinoma: In lung cancer, CARD-recruited membrane-associated protein 3 (CARMA3, which is a member of a family of caspase recruitment domain-containing scaffold proteins and membrane-associated guanylate kinase-like domain-containing proteins) regulates NME2 negatively by NF-κB-dependent induction of mir-182 to promote lung cancer stemness and metastasis [142].