MGMT and neoplasm: Among the tumor tissue samples, 51/89 (57.3%) showed MGMT promoter methylation.The specificity of the detection in the CSF and serum samples reached 100%.The sensitivity of MGMT promoter methylation detection in CSF and serum was 26/40 (65.0%) and 19/51 (37.3%), respectively (p < 0.05).