The findings from this study indicated elevated levels of immunosuppressive acidic proteins, including alpha-1 antitrypsin and alpha-1 acidic glycoprotein, as well as endothelial cell-derived thrombomodulin and glycoprotein fibronectin in glioma patients compared to those in both non-glioma individuals and healthy subjects [255]. This evidence concerns the gene THBD and central nervous system cancer.