To explore the participation of TGF-β signaling in the cellular immune response and survival ability of D. melanogaster in response to entomopathogenic nematode infection factors, we have injected 7 ng of H. bacteriophora rSCP into w1118 flies (Control) and Daw loss-of-function mutant flies (line Pbac{XP}daw05680), and 24 h later we have recorded numbers of circulating hemocytes. This evidence concerns the gene TGFB1 and Nematoda infectious disease.