Recently, Hsp40 and Hsp70 have been increasingly used in the treatment and prevention of fish diseases [49,50,51,52,53,54,55] and even in the human diseases, such as cancer [56,57,58,59], neurodegeneration [60,61,62], and autoimmune diseases [63,64,65,66,67]. This evidence concerns the gene DNAJB1 and fish disease.