A recent autopsy series published by Berger-Sieczkowski et al. identified two patients with short disease duration without the typical anti-IgLON5-related tauopathy who had extensive neuropil deposition of IgLON5-IgG4 in the brainstem tegmentum, olivary nucleus, and cerebellar cortex [15]. This evidence concerns the gene IGLON5 and tauopathy.