HLA-DRB1 and Cognitive impairment: Similarly, Gaig et al. reported that HLA-DRB1*10:01-positive patients were younger (median 64.5 years [range 46–77]) at diagnosis and more frequently presented with sleep or bulbar clinical phenotypes compared to HLA-DRB1*non-10:01 patients who were older (median 71 years [range 61–83]) at diagnosis and tended to present with PSP-like or cognitive impairment phenotypes; all of these findings reached statistical significance [17].