Adiponectin protects against WAT metaflammation and senescence, pancreatic β-cell senescence, hepatic steatosis and fibrosis, Kupffer cell activation and liver cirrhosis/hepatocellular carcinoma, hepatocyte and renal podocyte senescence, and premature aging and death [85,87,88] (Figure 5). This evidence concerns the gene ADIPOQ and hepatocellular carcinoma.