Knockout of miR-34a in HFD-fed obese mice attenuated VAT fibrosis, local (WAT CLS formation/M1 polarization) and systemic (serum cytokines: TNF-α, IL-6, IL-1β, and MCP-1) metaflammation, insulin resistance, and hepatic steatosis. The gene discussed is INS; the disease is fatty liver disease.