Upregulation of adiponectin and SIRT-1 expression after sleeve gastrectomy in a murine model of sequential HFD-induced obesity and streptozocin-induced T2DM resulted in browning of SAT via PPARγ, PGC-1α, and UCP1 activation [293]. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.