NLRP3 and obesity due to melanocortin 4 receptor deficiency: PD-L1 gene transcription is enhanced by activation of cGAS-STING, NF-κB, the NLRP3 inflammasome, and IFN-γ/JAK/STAT pathways, which leads to impaired immunosurveillance and decreased clearance of senescent cells during aging and obesity [309].