SIRT1 and obesity due to melanocortin 4 receptor deficiency: Luteolin also increases glucolipid metabolism (↑PPARγ, GLUT4), BAT and beige WAT thermogenesis (↑PGC1α, UCP-1), FAO (↑p-ACC, p-AMPK, CPT-1), VAT lipolysis (↑AMPK, SIRT-1), autophagy, and apoptosis (↑Caspase 3/8, ↓Bcl-2/Beclin1) and decreases WAT and liver lipogenesis (↓SREBP1, FASN, ACC), M1 and MMe macrophage polarization (↑p-STAT6,↓p-STAT3), NF-κB-mediated inflammation, and ROS (↑NFE2L2) in C57BL/6 mice models of obesity, NAFLD, and T2DM [335,336].