One proposed mechanism for AXL to enable these processes is through transcriptional regulation of MMP9 (another HUB gene in this study) [33]; Tai et al. [34] showed how, when AXL transcription increases, several cancer cell lines activate the Nf-κB pathway, concluding with an increase in MMP9 levels, a protein closely related to metastasis. The gene discussed is MMP9; the disease is cancer.