The overexpression of IRGs including Myxovirus resistance protein 1 (MX-1) and interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) has already been described in PBMCs [32,33], monocytes, and CD4 lymphocytes from SSc patients [34] but has not yet been investigated in B cells. This evidence concerns the gene CD4 and systemic sclerosis.