We have previously shown that the ligation of the TLR homolog CD180 induces the phosphorylation of PI3K/Akt and NF-κB in the B cells of patients with the more severe form of SSc, diffuse cutaneous SSc (dcSSc), to a significantly lesser extent than in healthy controls (HCs) [29,30]. The gene discussed is CD180; the disease is systemic sclerosis.