We showed the upregulation of two IRGs, MX-1 and IFIT-1, in the B cells of the dcSSc patients compared to the HCs suggesting the elevated activation of IFN-I signaling in the B cells of the dcSSc patients, which is consistent with the finding in SLE B cells [54,55]. The gene discussed is IFIT1; the disease is systemic lupus erythematosus.