IFNA1 and systemic sclerosis: The contribution of IFN-alpha (IFN-α) in the pathogenesis of autoimmune diseases was supported by the fact that IFN-α therapy of malignant tumors and hepatitis induced an increase in the prevalence of pathological autoantibodies and the development of various autoimmune diseases such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and rheumatoid arthritis (RA) [5,6].