Due to the effect of 2-HG on the TME in IDH-mutated gliomas, it is possible that 2-HG also contributes to the immunosuppressive phenotype of the TME in AML; however, the confirmation of this hypothesis requires further research covering, among other aspects, the mechanism of 2-HG transport to the TME [23,45]. This evidence concerns the gene IDH2 and central nervous system cancer.