Similarly, consistent with the results of this in vitro study, pitavastatin at 5 mg/kg and 10 mg/kg effectively reduced ki67 protein expression and enhanced cleaved caspase 3 and p38 phosphorylation protein expression in C-33 A xenograft tumor mice compared with the control group (Ki67, 10.1 ± 4.2 vs. 7.1 ± 1.6 vs. 4.1 ± 2.8 positive cells; cleaved caspase-3, 7.6 ± 2.1 vs. 19.6 ± 2.2 vs. 20.2 ± 4.1 positive cells; p-p38, 7.5 ± 2.4 vs. 16.3 ± 4.2 vs. 19.4 ± 4.4 positive cells, respectively; Figure 10, p < 0.05). This evidence concerns the gene CASP3 and neoplasm.