The proteins implicated in amyotrophic lateral sclerosis (ALS), including TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), superoxide dismutase 1 (SOD1), and chromosome 9 open reading frame 72 (C9orf72) repeat peptides, are also related to the DDR. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.