The proteins implicated in amyotrophic lateral sclerosis (ALS), including TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), superoxide dismutase 1 (SOD1), and chromosome 9 open reading frame 72 (C9orf72) repeat peptides, are also related to the DDR. Here, C9orf72 is linked to amyotrophic lateral sclerosis.