Several important questions remain, i.e., “Is tau involved in tubulin-dependent nuclear membrane invasion tract dynamics in neurons?”; “By what mechanism is tau converted from DSB repair function to toxic phosphorylated aggregates?”; “Does inhibition of DSB repair lead to NFT formation?”; and “What is the relationship between the formation of phosphorylated tau aggregates in glial cells and DSBs in other tauopathies?”. Here, MAPT is linked to tauopathy.