Resiniferatoxin, previously mentioned in this review for its potent agonist activity capable of desensitizing TRPV1 response, has been named as a “molecular scalpel” for chronic pain relief, especially in bone and arthritic pain deriving from bony metastases, osteosarcoma, and osteoarthritis [110,133,134]. This evidence concerns the gene TRPV1 and osteoarthritis.