TNF and COVID-19: In the study conducted by Huang et al. [7], high expression levels of IL-1B, IL-2, IL-4, IL-6, IL-7, IL-10, IFN-γ, IP-10, TNF-α, and monocyte chemoattractant protein 1 (MCP-1) were observed in COVID-19 patients, but also anti-inflammatory IL-4 and IL-10 secreted by Th2 cells, which is an example of the complexity of the cytokine storm mechanism [7,8,22].