Surprisingly, Xu L et al. reported that silencing of hepatic PRMT1 promoted steatosis in the livers of HFD-induced C57BL/6N mice via reduced PGC1α with no obvious changes in serum lipid contents, while overexpression of wild-type PRMT1 alleviated HFD-induced hepatic steatosis [24]. The gene discussed is PPARGC1A; the disease is fatty liver disease.