AGER and bronchopulmonary dysplasia: Interestingly, when Rage was homozygously overexpressed, in addition to the presence of the alveolar alterations described previously, a thickening of the alveolar interstitium, with hypercellular septa and abnormal vascular development, was observed due to a mild medial thickening and abnormalities in the architecture of elastic fibers; these histological alterations are also observed in human bronchopulmonary dysplasia [71].