This indicated not only persistent hyperglycemia but that hyperlipidemia induced chronic inflammation and contributes to increased reactive oxygen species (ROS) generation, impaired mitochondrial ATP production, decreased glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and increased glycation of essential advanced-glycation end proteins (AGEs) and protein kinase C [30,33,35]. The gene discussed is GAPDH; the disease is Hyperglycemia.