At first, increased plasma insulin levels in male BMP6−/− mice (Figure 3A), without concomitant difference in basal glucose levels (Figure 2C), seems paradoxical; however, in the literature, there are suggestions that hyperinsulinemia in mice could be due to the impaired insulin clearance [46] or increased free fatty acid concentration in plasma [47]. This evidence concerns the gene BMP6 and hyperinsulinism.