PRF1 and breast neoplasm: et al. have shown significant elimination of MDSC in the microenvironment of mice breast tumors treated with HDAC inhibitor SAHA (suberoylanilide hydroxamic acid, a potent inhibitor of HDAC1/2/3/6/7/11) that corresponds with an increased proportion of T cells (particularly that of IFN-γ- or perforin-producing CD8+ T cells) [79].