For all cell lines, ceralasertib reduced clonogenic survival in a dose-dependent manner, however, PTEN-depleted NSCLC cell lines had the greatest reduction in clonogenic survival in comparison to NT counterparts (0.12 μM and 0.16 μM vs. 0.19 μM and 0.19 μM for H460 and A549 PTEN-depleted vs. H460 and A549 NT cells, respectively). The gene discussed is PTEN; the disease is non-small cell lung carcinoma.