The acquired mutations that occur in MM can affect the genes that are involved in the control of cell proliferation, such as BRAF, NRAS, and NF1 genes; in cell metabolism, PTEN and KIT; in cell cycle control, the cyclin-dependent kinase inhibitor gene-CDKN2A (around 18% of the genetic mutations) and cyclin-dependent kinase 4 gene (CDK4); cell replication, telomerase reverse transcriptase TERT promoter; cell resistance to apoptosis, TP53; and cell identity, ARID2. This evidence concerns the gene CDK4 and Miyoshi myopathy.