MMP2 and neoplasm: MMP-2 (gelatinase A) (Table 1) is an endopeptidase that degrades previously cleaved ECM components (by collagenases), such as collagen IV from the basement membrane, as well as other non-fibrillar collagens (V, VII, X); gelatin; fibronectin; and type I, II and III collagen, enabling tumor cell progression.