MAP kinase signaling pathway, frequently associated with BRAF mutations (with the hyperactivation of Ras-Raf-MEK-ERK, as well as the over-activation of the PI3K-PTEN-AKT-mTOR pathway or RAC1B-FOXD1 pathway), leads to the over-expression of several genes involved in tumor uncontrolled growth, proliferation, and spread, such as MMP-9, as well as MMP-2 genes. Here, MMP2 is linked to neoplasm.