F2R and neoplasm: That is, MMP-1 acts in the progression of the MM through the cleavage of the dermal collagen, but it also promotes the development of tumor neovasculature by stimulating the NF-kB signaling pathway, the expression, and activation of several vascular growth factors, such as vascular endothelial growth factor (VEGF), activation of the VEGF pathway, endothelial cells proliferation, and by increasing the level of expression of PAR-1 [3,42,43].