TLR4 and neuropathy: Our results are in harmony with other studies which demonstrated the neuropathy of LPS through binding to TLR4 [3,31,33], activation of NF-κB [31,34] followed by the release of inflammatory cytokines [24,33,34,35], and ultimately taupathy [24,36,37,38] and amyloid plaque deposition [3,33,36].