IGF1R and myxoid liposarcoma: As for other genes, it has been reported that FUS-DDIT3 fusion mediates IGF-IR/PI3K/AKT signaling to activate YAP1, which plays a fundamental role in cell proliferation and survival, cooperatively regulating FUS-DDIT3 targets and aiding in FUS-DDIT3-mediated block of adipocyte differentiation, ultimately leading to the development of myxoid liposarcoma [53].