Lentiviral transduced MSCs with T/natural killer (NK) cell-targeting chemokine CXCL9 and immunostimulatory factor OX40 ligand (OX40)/tumor necrosis factor superfamily member 4 (TNFSF4) to tumor sites improve the recruitment of CD8+ T and NK cells and reduce the autoimmunity PD-1 and MHC-1 response [126]. This evidence concerns the gene TNFSF4 and Autoimmunity.