When knocking out Mth1 and Ogg1 genes in 3xTg-AD, a commonly used genetic AD mouse model, MTH1 and OGG1 deficiency leads to a significant increase in 8-oxoG accumulation in nuclear genomes, accelerating microglial activation, neuronal degeneration, and cognitive deficit at 4–5 months of age [45]. Here, OGG1 is linked to Alzheimer disease.