The biological processes related to cancer development, signaling, and response comprised 12 distinct hallmark pathways enriched with genes related to hypoxia, including Enolase 1 (ENO1), Triosephosphate isomerase (TPI-1), Decorin (DEC) Fos- proto-oncogene gene (FOS), and Aldolase-(ALDO). Here, ENO1 is linked to cancer.