Furthermore, sepsis-associated coagulopathy is characterized by a disbalance in the concentration of various procoagulant and anticoagulant proteins such as thrombomodulin, antithrombin, activated protein C (APC), tissue factor (TF), von Willebrand factor, and plasminogen activator inhibitor 1 (PAI-1) [15,20,32,45]. Here, SERPINE1 is linked to blood coagulation disease.