HEMGN and breast cancer: The decrease in Akt levels and the increase in AMPK and LC3A/B protein expression in our study indicate the same thing, and confirm that Se compounds, including our studied selenoesters EDAG-1 and EDAG-8, can affect the PI3K/Akt/mTOR and AMPK/mTOR signaling pathways to induce autophagy in the tested breast cancer cells.