HEMGN and breast carcinoma: Both the obtained results and Figure 10 suggest that the observed increase in the active form of caspase 9 in MCF-7 (estrogen-dependent) and MDA-MB-231 (estrogen-independent) breast cancer cells confirms previous studies (AV/PI and changes of ΔΨm assays) and is consistent with their findings, allowing us to conclude that compounds EDAG-1 and EDAG-8 can trigger apoptosis occurring via an intrinsic pathway.