Among the compounds upregulating caspase 8, we can distinguish, for example, selenadiazoles (HUVEC human umbilical vein endothelial cells and MCF-7 breast cancer cells), Se-methyl-L-selenocysteine (colon carcinoma cells, Colo205) [29], methylseleninic acid and sodium selenite (body-cavity-based lymphoma cells, BCBL1) [30], or ebselen (glioblastoma cells A172, T98G, and U87MG) [31]. Here, CASP8 is linked to colon carcinoma.