In the next step, we aimed to focus on the induction of apoptosis occurring via a mitochondrial-dependent (intrinsic) pathway; therefore, we evaluated the impact of the examined compounds (EDAG-1 and EDAG-8) and cisplatin on the mitochondrial membrane potential (∆Ψm) and the proteins responsible for this process (Bax and Bcl-2) in breast cancer cells (MCF-7 and MDA-MB-231) following a 24 h exposure to the compounds (concentrations of 0.5 and 1 μM). Here, BAX is linked to breast cancer.