Tumor necrosis factor-alpha (TNF-α) was discovered in 1975 as a molecule released into the bloodstream after reticuloendothelial system stimulation with bacterial lipopolysaccharide and was originally characterized as an anti-tumor and cytotoxic agent for many malignant cells, as it was capable of inducing the necrotic regression of certain tumors [1]. Here, TNF is linked to neoplasm.