Another autoinflammatory disorder with important skin manifestations is cryopyrin-associated periodic syndrome (CAPS), characterized by recurrent episodes of systemic inflammatory attacks in the absence of recognized infections or proven autoreactive manifestations [101]: a young boy with a severe form of CAPS was treated with etanercept, a TNF-α blocker consisting of a fusion protein fusing the TNFR to IgG1 antibody, obtaining a dramatic improvement of his joint symptoms, but not of his skin disease [102]. This evidence concerns the gene TNF and cryopyrin-associated periodic syndrome.