As seen in this review, a dysregulated activity of TNF-α can contribute to the pathogenesis of various skin disorders (see Table 1 for a list of the biological effects of TNF-α on different skin diseases): understanding its functions has led to the development of therapeutic strategies that might target TNF-α to manage at least a portion of inflammatory, autoimmune and autoinflammatory diseases seeing in TNF-α a pathogenic bedrock. This evidence concerns the gene TNF and skin disorder.