The identified pathways found to be most directly involved in host response to MAP are the nine pathways found to have a relationship to innate immune recognition of MAP and downstream inflammatory signaling (NOD-like receptor signaling, cell adhesion, phagosome, tuberculosis, NF-kappa-B signaling, Toll-like receptor signaling, Wnt signaling, IL-17 signaling pathway, and TNF signaling pathway). This evidence concerns the gene TNF and tuberculosis.