POLE and endometrial cancer: The TCGA publication in 2013 decoded endometrial cancer into four expanded subtypes as they have their characteristics, molecular features, and prognosis [25] (Table 1): (1) POLE ultra-mutated is characterized by a strong association with mutations in the exonuclease domain of polymerase-ε (POLE), a group of tumors with a good prognosis that could exclude the necessity of adjuvant treatment.