SIRT1 and cardiac hypertrophy: JIA et al. [66] found that in a spontaneously hypertensive rat model treated with capsaicin, there was an increase in SIRT1 and glutamate decarboxylase protein expression and the number of positive cells in plasma, a reduction in reactive oxygen species production, and a decrease in the relative expression of proteins in the MAPKs pathway, thereby alleviating hypertension and cardiac hypertrophy.