LI et al. [68] established a coronary atherosclerosis mouse model by feeding ApoE−/− mice a high-fat and high-sugar diet and found that SIRT1 can regulate the proliferation and migration of endothelial progenitor cells through the wnt/β-catenin/GSK3β signaling pathway, thereby alleviating damage in the coronary atherosclerosis mouse model. The gene discussed is SIRT1; the disease is coronary atherosclerosis.