In addition, Packer [98] indicated that it reduces the activation of SIRT1/PGC-1α/fibroblast growth factor and adenosine monophosphate-activated protein kinase and the inhibition of autophagy in type 2 diabetes, further causing mitochondrial dysfunction and oxidative stress and leading to myocardial fibrosis. This evidence concerns the gene SIRT1 and Myocardial fibrosis.