Sankaralingam et al. [101] found decreased cardiac SIRT1 expression, increased forkhead box O-class 1 acetylation, and increased atrogin-1 expression in an obese mouse model of HF, thereby reducing body weight, relieving myocardial hypertrophy, and improving diastolic function in obese mice. The gene discussed is SIRT1; the disease is cardiac hypertrophy.