PPARGC1A and cardiac hypertrophy: It has been shown that in a mouse model of pathological cardiac hypertrophy, downregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) following aberrant activation of the PI3K-AKT pathway in the heart caused a decrease in cardiac fatty acid oxidation and defects in mitochondrial function, leading to diastolic dysfunction [53].