FOXO3 and type 2 diabetes mellitus: YOU et al. [67] found in a diabetic cardiomyopathy (DCM) model using db/db mice that in type 2 diabetes, miR-200a-3p interacts with FOXO3 to promote Mst1 expression and reduce SIRT3 and AMPK expression, thereby improving diabetes-induced cardiac dysfunction, myocardial injury, myocardial fibrosis, and myocardial cell apoptosis.