PPARGC1A and hydrops fetalis: It has been found that SIRT1 interacts with and deacetylates PPARγ coactivator-1α in interleukin (IL) 6-deficient mice, and PPARγ coactivator-1α induces gluconeogenic genes, activates PGC-1α, enhances mitosis, restores energy metabolism in the myocardium, and improves HF [97].