TP53 and cardiac hypertrophy: SIRT7 is expressed in the nucleolus, and Vakhrusheva et al. [121] found that deletion of SIRT7 increased apoptosis in primary cardiomyocytes by approximately 200% by knocking out the SIRT7 gene in mice, and SIRT7 interacts with p53 in cardiomyocytes and can deacetylate p53, reduce cardiomyocyte death, and increase antioxidant stress response, thereby reducing cardiac hypertrophy (Figure 2).