He et al. [100] induced HFpEF with a high-salt diet model in the study and indicated that canagliflozin attenuates cardiac hypertrophy and fibrosis by activating p-adenosine 5′-monophosphate-activated protein kinase and SIRT1 to induce PGC-1α expression. The gene discussed is PPARGC1A; the disease is cardiac hypertrophy.