SIRTs ultimately function in cardiovascular diseases such as myocardial infarction, coronary atherosclerotic heart disease, and HF by regulating the eEF2K/eEF2 pathway, the 6 signaling pathway of SIRT1/transmembrane BAX inhibitor motif, the Sirt3/MnSOD pathway, and the AMPK/PGC-1α pathway, which are involved in maintaining metabolic homeostasis, inhibiting inflammation, counteracting apoptosis, and inhibiting oxidative stress-related processes [74]. Here, PPARGC1A is linked to hydrops fetalis.