AU-rich element RNA binding protein 1 (AUF1) and Human antigen R (HuR) are RNA-binding proteins that specifically interact with the ATX mRNA 3’-UTR, influencing ATX mRNA stability in LPS-stimulated THP-1 human monocytic cells and Colo320 human colon cancer (CR) cells [30]. Here, ENPP2 is linked to colonic neoplasm.