In this experiment, we also demonstrated that the ATX inhibition through IOA-289 treatment on different tumor cell lines of Prostatic Cancer (PC) (Panc-1, MIA PaCa-2), HCC (HLF, HLE), CCA (RBE, KKU-M213), and Colorectal Cancer (CRC) (HT-29, Caco2) led to reduction of cell proliferation and migration [78]. The gene discussed is ENPP2; the disease is pachyonychia congenita.